MORE THAN 25 YEARS OF PASSION FOR CHEMISTRY
STAND NR. 113

Alchemy is an Italian company established in 1998, dedicated to offering synthetic and analytical services to pharmaceutical and biotech Companies, along with providing research and development services to private and academic research Institutes. Our objective is to foster enduring partnerships with our Clients by delivering effective chemistry services and economical solutions.

CUSTOM SYNTHESIS
Since its inception, custom synthesis has been the primary focus of Alchemy. We specialize in preparing and characterizing various compounds, whether based on existing literature, customer protocols, or through the exploration and development of new synthetic routes.
Alchemy aids pharmaceutical companies in their Medicinal Chemistry endeavours across the preclinical stages of drug Research & Development.
Our custom synthesis services encompass the synthesis of:

• intermediates of research compounds and pharmaceuticals
• reference compounds of APIs and pharmaceuticals
• New Chemical Entities.

PROCESS DEVELOPMENT
Alchemy possesses the capability to swiftly develop scalable, reliable, and economical chemical processes optimizing reaction conditions for intermediates or final products.
• Evaluation, scouting and development of new synthesis for your target molecule
• Development of analytical methods for process and final control
• Scale-up of new routes in glass reactors (5-10L)
• Impurity profile determination

API IMPURITIES
Alchemy can carry out the identification and quantification of impurities in Active Pharmaceutical Ingredients (API) and formulated products. This activity is comprehensive, spanning all aspects of pharmaceutical production from research and development to the final market release.
• Impurity identification, isolation, and synthesis
• Impurity quantification
• Impurities genesis studies
• Degradation products studies

ANALYTICAL SERVICES and COLLABORATIONS
Alchemy’s analytical department is dedicated to analytical Research and Development (R&D) and Quality Control, serving both our internal synthetic department and pharmaceutical companies. We utilize advanced software, Fusion QbD, which enables us to expedite method development and validation in a more efficient manner.
Contact us for:
• Analytical standard qualification
• Analytical method development even by Quality by Design tools
• Analytical method validation
• Dissolution test.
We are authorized by the Italian Medicinal Agency (AIFA) to conduct Quality Control testing in adherence to Good Manufacturing Practices (GMP Certificate No. aM-72/2023).
Alchemy has the capability to develop and validate UPLC/HPLC methods for analysing Active Pharmaceutical Ingredients (API) and other chemical entities.
Since 2021, Alchemy has partnered with S-Matrix® and Waters® to assist Italian users of Fusion QbD®, the S-Matrix® software platform for developing LC methods in accordance with the ICH Q14 guideline. Our services comprise on-site and web user training, as well as continuous technical analytical support.